Comboguard (spinosad 810 mg milbemycin oxime 13.5 mg) Dailymed
Prescription Animal - Archived
- Vicar Operating Inc
Generic: spinosad and milbemycin oxime
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(spinosad + milbemycin oxime)
Chewable Tablets
Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Description:
COMBOGUARD (spinosad and milbemycin oxime) is available in five sizes for oral administration to dogs and puppies according to their weight. Each chewable flavored tablet is formulated to provide a minimum spinosad dose of 13.5 mg/lb (30 mg/kg) and a minimum milbemycin oxime dose of 0.2 mg/lb (0.5 mg/kg). Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa.
Spinosyn A and spinosyn D have the chemical compositions C41H65NO10 and C42H67NO10, respectively. Milbemycin oxime is a macrocyclic lactone anthelmintic, containing two major factors, A3 and A4 of milbemycin oxime. The approximate ratio of A3:A4 is 20:80. Milbemycin A4 5-oxime has the chemical composition of C32H45NO7 and milbemycin A3 5-oxime has the chemical composition of C31H43NO7.
Indications:
COMBOGUARD is indicated for the prevention of heartworm disease (Dirofilaria immitis). COMBOGUARD kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
Dosage And Administration:
COMBOGUARD is given orally, once a month at the minimum dosage of
13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes (see EFFECTIVENESS ).
Dosage Schedule:
Body Weight
SpinosadPer Tablet (mg)
Milbemycin oximePer Tablet (mg)
TabletsAdministered
5 to 10 lbs
140
2.3
One
10.1 to 20 lbs
270
4.5
One
20.1 to 40 lbs
560
9.3
One
40.1 to 60 lbs
810
13.5
One
60.1 to 120 lbs
1620
27
One
Over 120 lbs
Administer the appropriate combination of tablets
Administer COMBOGUARD with food for maximum effectiveness. To ensure heartworm prevention, owners should observe the dog for one hour after dosing. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of COMBOGUARD with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations.
Heartworm Prevention:
COMBOGUARD should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure and continuing until at least 3 months after the dog's last seasonal exposure to mosquitoes (see EFFECTIVENESS ). COMBOGUARD may be administered year round without interruption. When replacing another heartworm preventative product, the first dose of COMBOGUARD should be given within a month of the last dose of the former medication.
Flea Treatment and Prevention:
Treatment with COMBOGUARD may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with COMBOGUARD should continue the entire year without interruption.
To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.
Intestinal Nematode Treatment and Control:
COMBOGUARD also provides treatment and control of roundworms (T. canis, T. leonina), hookworms (A. caninum) and whipworms (T. vulpis). Dogs may be exposed to and can become infected with roundworms, whipworms and hookworms throughout the year, regardless of season or climate. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
Contraindications:
There are no known contraindications to the use of COMBOGUARD.
Warnings:
Not for human use. Keep this and all drugs out of the reach of children. Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, a component of COMBOGUARD (see ADVERSE REACTIONS ).
Precautions:
Treatment with fewer than 3 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see EFFECTIVENESS ).
Prior to administration of COMBOGUARD, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. COMBOGUARD is not effective against adult D. immitis. While the number of circulating microfilariae may decrease following treatment, COMBOGUARD is not indicated for microfilariae clearance (see ANIMAL SAFETY ).
Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.
Use with caution in breeding females (see ANIMAL SAFETY ). The safe use of COMBOGUARD in breeding males has not been evaluated.
Use with caution in dogs with pre-existing epilepsy (see ADVERSE REACTIONS ).
Puppies less than 14 weeks of age may experience a higher rate of vomiting (see ANIMAL SAFETY ).
Adverse Reactions:
In a well-controlled US field study, which included a total of 352 dogs (176 treated with COMBOGUARD and 176 treated with an active control), no serious adverse reactions were attributed to administration of COMBOGUARD. All reactions were regarded as mild.
Over the 180-day study period, all observations of potential adverse reactions were recorded. Reactions that occurred at an incidence >1% (average monthly rate) within any of the 6 months of observation are presented in the following table. The most frequently reported adverse reaction in dogs in the COMBOGUARD group was vomiting.
Average Monthly Rate (%) of Dogs With Adverse Reactions an=176 dogs
Adverse Reaction
COMBOGUARD Chewable Tabletsa
Active Control Tabletsa
Vomiting
6.13
3.08
Pruritus
4.00
4.91
Lethargy
2.63
1.54
Diarrhea
2.25
1.54
Dermatitis
1.47
1.45
Skin Reddening
1.37
1.26
Decreased appetite
1.27
1.35
Pinnal Reddening
1.18
0.87
In the US field study, one dog administered COMBOGUARD experienced a single mild seizure 2 ½ hours after receiving the second monthly dose. The dog remained enrolled and received four additional monthly doses after the event and completed the study without further incident.
Following concomitant extra-label use of ivermectin with spinosad alone, a component of COMBOGUARD, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation. Spinosad alone has been shown to be safe when administered concurrently with heartworm preventatives at label directions.
In US and European field studies, no dogs experienced seizures when dosed with spinosad alone at the therapeutic dose range of 13.5-27.3 mg/lb (30-60 mg/kg), including 4 dogs with pre-existing epilepsy. Four epileptic dogs that received higher than the maximum recommended dose of 27.3 mg/lb (60 mg/kg) experienced at least one seizure within the week following the second dose of spinosad, but no seizures following the first and third doses. The cause of the seizures observed in the field studies could not be determined.
For technical assistance or to report a suspected adverse drug reaction, call 1-888-545-5973. Additional information can be found at www.vethical.com. Alternatively, suspected adverse drug reactions may be reported to FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth/ReportaProblem/ucm055305.htm
Post Approval Experience (mar 2012):
The following adverse reactions are based on post-approval adverse drug event reporting. The adverse reactions are uled in decreasing order of frequency: vomiting, depression/lethargy, pruritus, anorexia, diarrhea, trembling/shaking, ataxia, seizures, hypersalivation, and skin reddening.
Mode Of Action:
The primary target of action of spinosad, a component of COMBOGUARD, is an activation of nicotinic acetylcholine receptors (nAChRs) in insects. Spinosad does not interact with known insecticidal binding sites of other nicotinic or GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins and cyclodienes. Insects treated with spinosad show involuntary muscle contractions and tremors resulting from activation of motor neurons. Prolonged spinosad-induced hyperexcitation results in prostration, paralysis and flea death. The selective toxicity of spinosad between insects and vertebrates may be conferred by the differential sensitivity of the insect versus vertebrate nAChRs.
Milbemycin oxime, a component of COMBOGUARD, acts by binding to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells. Increased permeability by the cell membrane to chloride ions causes hyperpolarization of affected cells and subsequent paralysis and death of the intended parasites. Milbemycin oxime may also act by disrupting the transmission of invertebrate neurotransmitters, notably gamma amino butyric acid (GABA).
Effectiveness:
Heartworm Prevention:
In a well-controlled laboratory study, COMBOGUARD was 100% effective against induced heartworm infections when administered for 3 consecutive monthly doses. Two consecutive monthly doses did not provide 100% effectiveness against heartworm infection. In another well-controlled laboratory study, a single dose of COMBOGUARD was 100% effective against induced heartworm infections.
In a well-controlled six-month US field study conducted with COMBOGUARD, no dogs were positive for heartworm infection as determined by heartworm antigen testing performed at the end of the study and again three months later.
Flea Treatment and Prevention:
In a well-controlled laboratory study, COMBOGUARD demonstrated 100% effectiveness on the first day following treatment and 100% effectiveness on Day 30. In a well-controlled laboratory study, spinosad, a component of COMBOGUARD, began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours. Spinosad, a component of COMBOGUARD, kills fleas before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0% to 99.8% were observed over the course of 3 monthly treatments with spinosad alone. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating the fleas.
Treatment and Control of Intestinal Nematode Infections:
In well-controlled laboratory studies, COMBOGUARD was ≥ 90% effective in removing naturally and experimentally induced adult roundworm, whipworm and hookworm infections.
Palatability:
COMBOGUARD is a flavored chewable tablet. In a field study of client-owned dogs where 175 dogs were each offered COMBOGUARD once a month for 6 months, dogs voluntarily consumed 54% of the doses when offered plain as if a treat, and 33% of the doses when offered in or on food. The remaining 13% of doses were administered like other tablet medications.
Animal Safety:
COMBOGUARD was tested in pure and mixed breeds of healthy dogs in well-controlled clinical and laboratory studies. No dogs were withdrawn from the field studies due to treatment-related adverse reactions.
In a margin of safety study, COMBOGUARD was administered orally to 8-week-old Beagle puppies at doses of 1, 3, and 5 times the upper half of the therapeutic dose band, every 28 days for 6 dosing periods. Vomiting was seen in all groups including control animals with similar frequency. Adverse reactions seen during the course of the study were salivation, tremors, decreased activity, coughing and vocalization.
Body weights were similar between control and treated groups throughout the study. Treatment with COMBOGUARD was not associated with any clinically significant hematology, clinical chemistry or gross necropsy changes. One 5X dog had minimal glomerular lipidosis observed microscopically. The clinical relevance of this finding is unknown.
Plasma spinosyn A, spinosyn D, milbemycin A3 5-oxime and milbemycin A4 5-oxime concentrations increased throughout the study. At each dosing period, plasma spinosyn A and spinosyn D concentrations were greater than proportional across the dose range 1 to 5X. Plasma milbemycin A4 5-oxime concentrations appeared to be dose proportional across range 1 to 5X by the end of the study. Plasma concentrations of spinosad and milbemycin oxime indicate that expected systemic exposures were achieved throughout the study.
In an avermectin-sensitive Collie dog study, COMBOGUARD was administered orally at 1, 3, and 5 times the upper half of the recommended therapeutic dose band every 28 days. No signs of avermectin sensitivity were observed after administration of COMBOGUARD during the study period to avermectin-sensitive Collie dogs. The adverse reactions observed in the treatment groups were vomiting and diarrhea. Body weights in all treatment groups were comparable to the control group. Hematology and clinical chemistry parameters showed no clinically significant changes from study start to end, and all dogs were considered healthy throughout the study.
In a heartworm positive safety study, COMBOGUARD was administered orally at 1, 3, and 5 times the upper half of the therapeutic dose band to Beagle dogs with adult heartworm infections and circulating microfilariae, every 28 days for 3 treatments. Vomiting was observed in one dog in the 1X group, in three dogs in the 3X group, and in one dog in the 5X group. All but one incident of vomiting was observed on the treatment day during the first treatment cycle. The vomiting was mild and self-limiting. Hypersensitivity reactions were not observed in any of the treatment groups. Microfilariae counts decreased with treatment.
In a reproductive safety study, COMBOGUARD was administered orally to female dogs at 1 and 3 times the upper half of the therapeutic dose band every 28 days prior to mating, during gestation and during a six-week lactation period. Dogs with confirmed fetal heartbeats on ultrasound examination were evaluated for reproductive safety. One 3X and one 1X group female did not become pregnant. No treatment-related adverse reactions or signs of avermectin toxicosis were noted for adult females. Adult females in the 3X group lost weight during the 6-week pre-mating period, while control group females gained weight during that time. The body weights of the treated groups were comparable to the control group during gestation and post-parturition phases of the study. Gestation length, litter average body weight, litter size, stillborn pups, pup survival and the proportion of pups with malformations were comparable between treated and control dam groups. Malformations in the 1X group included a pup with cleft palate and a littermate with anophthalmia, fused single nares, misshapen palate, hydrocephalus, omphalocele and malpositioned testes; a pup with a malformation of the anterior tip of the urinary bladder and umbilical blood vessel; and a pup with patent ductus arteriosus (PDA). Malformations in the 3X group included three littermates with PDA. Malformations in the control group included a pup with a malformed sternum and a pup with PDA and a malpositioned superior vena cava. Clinical findings in pups of the treated groups were comparable to the control group except for one 1X group pup that was smaller and less coordinated than its littermates and had tremors when excited. The relationship between spinosad and milbemycin oxime treatment and the 1X and 3X dogs that did not become pregnant, the specific pup malformations and the unthrifty 1X group pup are unknown. The incidence of cleft palate is not unexpected based on the historical data collected at the breeding site.
In a margin of safety study with spinosad alone, 6-week old Beagle puppies were administered average doses of 1.5, 4.4, and 7.4 times the maximum recommended dose at 28-day intervals over a 6-month period. Vomiting was observed across all treatments, including controls, and was observed at an increased rate at elevated doses. Vomiting most often occurred 1 hour following administration and decreased over time and stabilized when puppies reached 14 weeks of age.
Storage Information:
Store at 20-25°C (68-77°F), excursions permitted between 15-30°C (59-86°F).
How Supplied:
COMBOGUARD is available in five tablet sizes. Each tablet size is available in color-coded packages of 6 tablets.
5-10 lbs (140 mg spinosad and 2.3 mg milbemycin oxime)10.1-20 lbs (270 mg spinosad and 4.5 mg milbemycin oxime)20.1-40 lbs (560 mg spinosad and 9.3 mg milbemycin oxime)40.1-60 lbs (810 mg spinosad and 13.5 mg milbemycin oxime)60.1-120 lbs (1620 mg spinosad and 27 mg milbemycin oxime)
NADA 141-321, Approved by the FDA
Distributed by Vicar Operating, Inc.
12401 West Olympic Blvd.
Los Angeles, CA 90064
All trademarks are the property of their respective owners.All rights reserved.
NDC 50386-4332-7NDC 50386-4333-7NDC 50386-4334-7NDC 50386-4335-7NDC 50386-4336-7CA4332Y07AMC1CA4333Y07AMC1CA4334Y07AMC1CA4335Y07AMC1CA4336Y07AMC1
Information For Owners/caregivers Section
Your veterinarian has chosen to prescribe COMBOGUARD Chewable Tablets for the prevention of heartworm disease (Dirofilaria immitis), to kill fleas and for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Controlling these parasites is very important to the health of your dog. Please read this leaflet, which describes the proper use of COMBOGUARD. If you have any questions about this information, please consult your veterinarian. Additional information can be found at www.vethical.com.
What is COMBOGUARD?
COMBOGUARD is a chewable, flavored tablet that you give orally to your dog once-a-month to kill fleas, to prevent flea infestations, to treat and control hookworms, whipworms and roundworms, and to prevent heartworm disease. COMBOGUARD is for monthly use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer COMBOGUARD monthly throughout the year, the final dose must be given no fewer than three months following the last exposure to mosquitoes.
Why has my veterinarian prescribed COMBOGUARD?
Your veterinarian has prescribed COMBOGUARD as a way of preventing your dog from developing problems caused by infection with three commonly occurring parasite categories. Heartworm infection can make dogs very sick and can even be fatal. This parasite is spread to dogs by mosquitoes. COMBOGUARD can prevent flea infestations from becoming established, and can also remove any fleas that are on your dog at the time of treatment. COMBOGUARD will also treat and control common adult intestinal worm infections (roundworms, hookworms and whipworms).
Should I give COMBOGUARD each month all year round? Consult your veterinarian regarding the need for year round use of COMBOGUARD. If you do not administer COMBOGUARD monthly throughout the year, the final dose must be given no fewer than three months following the last exposure to mosquitoes.
Will COMBOGUARD kill heartworms?
COMBOGUARD prevents heartworm disease by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventatives, COMBOGUARD does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.
Will my dog still need to be tested for heartworm infection while taking COMBOGUARD?
You should speak to your veterinarian about the frequency of heartworm testing while your dog is taking COMBOGUARD.
How do I switch to COMBOGUARD from another heartworm preventative?
Follow the advice of your veterinarian about switching heartworm preventatives.
What should I discuss with my veterinarian regarding COMBOGUARD for my dog?
Your veterinarian is your dog's healthcare expert and can make the best recommendation for medications for your dog. This includes the prevention, control and/or treatment of parasites such as fleas, heartworms and intestinal parasites that may cause conditions that include flea allergy dermatitis, anemia and heart disease. Key points of your discussion may include the following:
• As with other heartworm preventatives, dogs should be tested for heartworm prior to beginning treatment with COMBOGUARD.• If a dose is missed and a monthly interval between doses is exceeded, then immediately give COMBOGUARD with food and resume monthly dosing. This practice will minimize the opportunity for heartworms to grow. Also, continuing normal monthly dosing will allow you to gain control of any flea or intestinal parasites that might have infected your dog.• To minimize the likelihood of fleas continuing to jump onto your dog, it is important to treat all household pets with an approved flea protection product.• COMBOGUARD is not for use in humans. Like all medications, keep COMBOGUARD out of reach of children.
How should I give COMBOGUARD to my dog?
Give COMBOGUARD with food for maximum effectiveness. COMBOGUARD is a chewable tablet and may be offered as a treat. Consult your veterinarian regarding the need for year round administration of COMBOGUARD. To help you remember the monthly dosing schedule, stick-on labels are included for your calendar.
What if I give more than the prescribed amount of COMBOGUARD to my dog?
Contact your veterinarian as soon as possible if you believe your dog has ingested more than the recommended dose of COMBOGUARD. In a study in which dogs were dosed at 1, 3, and 5 times the upper half of the recommended dose, dogs exhibited vomiting, tremors, decreased activity, salivation, coughing and vocalization.
Should I restrict either my dog's activity or contact with my dog after the tablet is consumed?
Since COMBOGUARD is an oral formulation, you may maintain normal activities and interactions with your dog.
How quickly will COMBOGUARD kill fleas?
In a laboratory study of spinosad alone, an active ingredient of COMBOGUARD, spinosad started to kill fleas within 30 minutes and killed 100% of the fleas within 4 hours. COMBOGUARD kills fleas before they can lay eggs.
Does seeing fleas on my dog mean that the treatment is not working?
COMBOGUARD kills fleas before they can lay eggs when used monthly according to the label directions. Remember that all animals in the household should be treated with an approved flea product to help control the flea population.
Your dog can continue to be exposed to the fleas that live in the environment. When fleas jump onto your dog, they will be killed by COMBOGUARD.
If within a month after your dog receives COMBOGUARD you see fleas on your dog, it is most likely that these are new fleas. These new fleas will be killed before they can produce eggs that contaminate the environment. Continued monthly use of COMBOGUARD can prevent any new infestations.
What if I see worms in my dog's stool during the month after administration of COMBOGUARD?
COMBOGUARD is indicated to treat and control intestinal parasite infections of adult hookworms, roundworms and whipworms. In occasional cases, it is possible that the action of COMBOGUARD in killing the intestinal worms will lead to the dog expelling them in the stool. If you have questions, consult with your veterinarian for measures you can take to prevent a reinfection with intestinal parasites.
Is it safe to give my dog COMBOGUARD?
COMBOGUARD has been demonstrated to be safe in pure and mixed breeds of healthy dogs when used according to label directions for dogs and puppies 8 weeks of age and older and five pounds of body weight or greater. You should discuss the use of COMBOGUARD with your veterinarian prior to use if your dog has a history of epilepsy (seizures). Puppies less than 14 weeks of age may experience a higher rate of vomiting.
Is it safe to give my breeding dogs COMBOGUARD?
Ask your veterinarian about the use of COMBOGUARD prior to use in breeding females. The safe use of COMBOGUARD in male dogs intended for breeding has not been evaluated.
What side effects might occur with COMBOGUARD?
Like all medications, sometimes side effects may occur. In some cases, dogs vomited after receiving COMBOGUARD. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.
Since the introduction of COMBOGUARD, additional side effects reported are trembling/shaking, ataxia, seizures and hypersalivation.
For technical assistance or to report a suspected adverse drug reaction, call 1-888-545-5973. Additional information can be found at www.vethical.com. Alternatively, suspected adverse drug reactions may be reported to FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth/ReportaProblem/ucm055305.htm
Can other medications be given while my dog is taking COMBOGUARD?
Yes, COMBOGUARD has been given safely with a wide variety of products and medications. Your veterinarian should be made aware of all products that you administered and/or intend to administer to your dog.
How should COMBOGUARD be stored?
Store at 68-77°F (20-25°C). Temporary periods of time outside this range between 59-86°F (15 -30°C) are permitted.
All trademarks are the property of their respective owners. All rights reserved.
NDC 50386-4332-7Â Â Â Â Â Â CA4332Y07AMC1NDC 50386-4333-7Â Â Â Â Â Â CA4333Y07AMC1NDC 50386-4334-7Â Â Â Â Â Â CA4334Y07AMC1NDC 50386-4335-7Â Â Â Â Â Â CA4335Y07AMC1NDC 50386-4336-7Â Â Â Â Â Â CA4336Y07AMC1
PA086261AMB (V01-07-2012)
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
5-10 lbs
6 CHEWABLE TABLETS
140 mg spinosad/2.3 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
5-10 lbs
6 CHEWABLE TABLETS
140 mg spinosad/2.3 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
(spinosad+milbemycin oxime)
For Dogs and Puppies 5-10 lbs
8 weeks of age and older and
5 pounds of body weight or greater
140 mg spinosad + 2.3 mg milbemycin oxime
(Give with a meal)
--------------
Puncture Here
Distributed by Vicar Operating, Inc.
Los Angeles, CA 90064
Lot #
Exp.
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
10.1-20 lbs
6 CHEWABLE TABLETS
270 mg spinosad/4.5 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
10.1-20 lbs
6 CHEWABLE TABLETS
270 mg spinosad/4.5 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
(spinosad+milbemycin oxime)
For Dogs and Puppies 10.1-20 lbs
8 weeks of age and older and
5 pounds of body weight or greater
270 mg spinosad + 4.5 mg milbemycin oxime
(Give with a meal)
--------------
Puncture Here
Distributed by Vicar Operating, Inc.
Los Angeles, CA 90064
Lot #
Exp.
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
20.1-40 lbs
6 CHEWABLE TABLETS
560 mg spinosad/9.3 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
20.1-40 lbs
6 CHEWABLE TABLETS
560 mg spinosad/9.3 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
(spinosad+milbemycin oxime)
For Dogs and Puppies 20.1-40 lbs
8 weeks of age and older and
5 pounds of body weight or greater
560 mg spinosad + 9.3 mg milbemycin oxime
(Give with a meal)
--------------
Puncture Here
Distributed by Vicar Operating, Inc.
Los Angeles, CA 90064
Lot #
Exp.
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
40.1-60 lbs
6 CHEWABLE TABLETS
810 mg spinosad/13.5 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
40.1-60 lbs
6 CHEWABLE TABLETS
810 mg spinosad/13.5 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
(spinosad+milbemycin oxime)
For Dogs and Puppies 40.1-60 lbs
8 weeks of age and older and
5 pounds of body weight or greater
810 mg spinosad + 13.5 mg milbemycin oxime
(Give with a meal)
--------------
Puncture Here
Distributed by Vicar Operating, Inc.
Los Angeles, CA 90064
Lot #
Exp.
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
60.1-120 lbs
6 CHEWABLE TABLETS
1620 mg spinosad/27 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
FOR DOGS
60.1-120 lbs
6 CHEWABLE TABLETS
1620 mg spinosad/27 mg milbemycin oxime
(spinosad+milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or
on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older and 5 lbs of bodyweight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH a Meal
Vethical®
![]()
Package Label.principal Display Panel
ComboGuard®
(spinosad+milbemycin oxime)
For Dogs and Puppies 60.1-120 lbs
8 weeks of age and older and
5 pounds of body weight or greater
1620 mg spinosad + 27 mg milbemycin oxime
(Give with a meal)
--------------
Puncture Here
Distributed by Vicar Operating, Inc.
Los Angeles, CA 90064
Lot #
Exp.
![]()
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