Carbidopa 25 MG Levodopa 250 MG Oral Tablet Sinemet

INDICATIONS AND USAGE SINEMET is indicated in the treatment of Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism that may follow carbon monoxide intoxication or manganese intoxication. Carbidopa allows patients treated for Parkinson's disease to use much lower doses of levodopa. Some patients who responded poorly to levodopa have improved on SINEMET. This is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous system. Carbidopa has not been shown to enhance the intrinsic efficacy of levodopa. Carbidopa may also reduce nausea and vomiting and permit more rapid titration of levodopa.

Merck Sharp & Dohme Corp.

FDA Reported Adverse Reactions
`[1] drug ineffective` `[2] off label use` `[3] fatigue` `[4] pain` `[5] dyspnoea` `[6] arthralgia` `[7] nausea` `[8] diarrhoea` `[9] headache` `[10] condition aggravated`

5 years ago

ROUND BLUE 654

HOW SUPPLIED For SINEMET Manufactured by Mylan No. 3916A — SINEMET 25-100 Tablets are yellow, round, uncoated tablets, that are coded "650" on one side and plain on the other. They are supplied as follows: NDC 0006-3916-68 bottles of 100. No. 3915 — SINEMET 10-100 Tablets are light dapple-blue, round, uncoated tablets, that are coded "647" on one side and plain on the other. They are supplied as follows: NDC 0006-3915-68 bottles of 100. No. 3917 — SINEMET 25-250 Tablets are light dapple-blue, round, uncoated tablets, that are coded "654" on one side and plain on the other. They are supplied as follows: NDC 0006-3917-68 bottles of 100. For SINEMET Manufactured by Savio No. 6724 — SINEMET 25-100 Tablets are yellow oval tablets that are plain on one side, with "650" and a score line on the other. They are supplied as follows: NDC 0006-6724-68 bottles of 100. No. 6722 — SINEMET 10-100 Tablets are dark dapple-blue oval tablets that are plain on one side, with "647" and a score line on the other. They are supplied as follows: NDC 0006-6722-68 bottles of 100. No. 6723 — SINEMET 25-250 Tablets are light dapple-blue oval tablets that are plain on one side, with "654" and a score line on the other. They are supplied as follows: NDC 0006-6723-68 bottles of 100. Storage and Handling Store at 25°C (77°F), excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Store in a tightly closed container, protected from light and moisture. Dispense in a tightly closed, light-resistant container.

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