nitrofurantoin 100 MG nitrofurantoin macrocrystals 25 MG nitrofurantoin monohydrate 75 MG Oral Capsule
INDICATIONS AND USAGE Nitrofurantoin macrocrystals is specifically indicated for the treatment of urinary tract infections when due to susceptible strains of Escherichia coli , enterococci, Staphylococcus aureus , and certain susceptible strains of Klebsiella and Enterobacter species. Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses. To reduce the development of drug-resistant bacteria and maintain the effectiveness of nitrofurantoin macrocrystals and other antibacterial drugs, nitrofurantoin macrocrystals should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Nitrofurantoins lack the broader tissue distribution of other therapeutic agents approved for urinary tract infections. Consequently, many patients who are treated with nitrofurantoin macrocrystals are predisposed to persistence or reappearance of bacteriuria. Urine specimens for culture and susceptibility testing should be obtained before and after completion of therapy. If persistence or reappearance of bacteriuria occurs after treatment with nitrofurantoin macrocrystals, other therapeutic agents with broader tissue distribution should be selected. In considering the use of nitrofurantoin macrocrystals, lower eradication rates should be balanced against the increased potential for systemic toxicity and for the development of antimicrobial resistance when agents with broader tissue distribution are utilized.
Physicians Total Care, Inc.
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HOW SUPPLIED Nitrofurantoin Macrocrystals capsules USP are available as pink opaque/white opaque capsules, imprinted with , “Zenith 50 mg” on the cap and “2130”, underlined with a double bar, on the body, in black ink, containing 50 mg nitrofurantoin macrocrystals, packaged in Bottles of 10 NDC 54868-0107-7 Bottles of 20 NDC 54868-0107-6 Bottles of 30 NDC 54868-0107-5 Bottles of 40 NDC 54868-0107-2 Nitrofurantoin Macrocrystals capsules USP are available as pink opaque capsules, imprinted with , “Zenith 100 mg” on the cap and “2131”, underlined with a triple bar, on the body, in black ink, containing 100 mg nitrofurantoin macrocrystals, packaged in Bottles of 06 NDC 54868-0473-6 Bottles of 10 NDC 54868-0473-5 Bottles of 14 NDC 54868-0473-1 Bottles of 15 NDC 54868-0473-3 Bottles of 20 NDC 54868-0473-2 Bottles of 30 NDC 54868-0473-4 Bottles of 60 NDC 54868-0473-7 Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required). Imprinted logo Imprinted logo
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